Title: Targeting 5-Lipoxygenase Signaling Pathways to Reverse Drug Resistance in Cancer
VOLUME: 3 ISSUE: 7
Author(s):Alfonso Catalano and Antonio Procopio
Affiliation:Dipartimento di Patologia Molecolare e Terapie Innovative, Universita Politecnica delle Marche, Via Ranieri, 60131, Ancona, Italy.
Keywords:5-lipoxygenase, Eicosanoids, Cancer therapy, Lipoxygenase inhibitors
Abstract: 5-Lipoxygenase, which leads to the biosynthesis of proinflammatory lipid mediators, is involved in the pathogenesis of cancer. Experimental studies have demonstrated that 5-lipoxygenase inhibitors have antitumoral properties. Here, we describe the compelling evidence that 5-lipoxygenase inhibition is a rational therapy for certain cancers and for adjuvant approaches to cancer therapy.
