Targeting 5-Lipoxygenase Signaling Pathways to Reverse Drug Resistance in Cancer

Author(s): Alfonso Catalano, Antonio Procopio

Journal Name: Letters in Drug Design & Discovery

Volume 3 , Issue 7 , 2006

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5-Lipoxygenase, which leads to the biosynthesis of proinflammatory lipid mediators, is involved in the pathogenesis of cancer. Experimental studies have demonstrated that 5-lipoxygenase inhibitors have antitumoral properties. Here, we describe the compelling evidence that 5-lipoxygenase inhibition is a rational therapy for certain cancers and for adjuvant approaches to cancer therapy.

Keywords: 5-lipoxygenase, Eicosanoids, Cancer therapy, Lipoxygenase inhibitors

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Article Details

Year: 2006
Page: [459 - 461]
Pages: 3
DOI: 10.2174/157018006778194817
Price: $65

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