Abstract
Acting as a redox switch, folic acid (1) might be a promising iron modulator to protect cellular machinery against oxidative stress and iron overload. The vitamin 1 can directly control the iron concentration by oxidizing it even if present in chelated forms. In addition, during its role as a reducing agent for the biologically relevant reactive oxygen species (ROS), it furnishes 6-formyl pterin. This folate-derived intermediate possesses a stronger Fe2+-oxidizing capacity than 1. Thus, compound 1 can reduce the iron toxicity in two ways. Although, the Fe2+-oxidizing capacity is nullified in the presence of a strong biological reductant like ascorbic acid, this property may play a predominant role during pathogenesis when the cellular ascorbic acid levels deplete significantly. The iron-modulatory property of 1 was also confirmed with the L929 mouse fibroblast cell line.
Keywords: ferrozine assay, Oxidative degradation, intracellular folate pool, Deoxyribose Assay, Iron chelation
Medicinal Chemistry
Title: Folic Acid as a Fenton-modulator: Possible Physiological Implication
Volume: 2 Issue: 4
Author(s): Subrata Chattopadhyay, Birija S. Patro, Soumyakanti Adhikari and Tulsi Mukherjee
Affiliation:
Keywords: ferrozine assay, Oxidative degradation, intracellular folate pool, Deoxyribose Assay, Iron chelation
Abstract: Acting as a redox switch, folic acid (1) might be a promising iron modulator to protect cellular machinery against oxidative stress and iron overload. The vitamin 1 can directly control the iron concentration by oxidizing it even if present in chelated forms. In addition, during its role as a reducing agent for the biologically relevant reactive oxygen species (ROS), it furnishes 6-formyl pterin. This folate-derived intermediate possesses a stronger Fe2+-oxidizing capacity than 1. Thus, compound 1 can reduce the iron toxicity in two ways. Although, the Fe2+-oxidizing capacity is nullified in the presence of a strong biological reductant like ascorbic acid, this property may play a predominant role during pathogenesis when the cellular ascorbic acid levels deplete significantly. The iron-modulatory property of 1 was also confirmed with the L929 mouse fibroblast cell line.
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Cite this article as:
Chattopadhyay Subrata, Patro S. Birija, Adhikari Soumyakanti and Mukherjee Tulsi, Folic Acid as a Fenton-modulator: Possible Physiological Implication, Medicinal Chemistry 2006; 2 (4) . https://dx.doi.org/10.2174/157340606777724059
DOI https://dx.doi.org/10.2174/157340606777724059 |
Print ISSN 1573-4064 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6638 |
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