Folic Acid as a Fenton-modulator: Possible Physiological Implication

Author(s): Subrata Chattopadhyay, Birija S. Patro, Soumyakanti Adhikari, Tulsi Mukherjee

Journal Name: Medicinal Chemistry

Volume 2 , Issue 4 , 2006

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Acting as a redox switch, folic acid (1) might be a promising iron modulator to protect cellular machinery against oxidative stress and iron overload. The vitamin 1 can directly control the iron concentration by oxidizing it even if present in chelated forms. In addition, during its role as a reducing agent for the biologically relevant reactive oxygen species (ROS), it furnishes 6-formyl pterin. This folate-derived intermediate possesses a stronger Fe2+-oxidizing capacity than 1. Thus, compound 1 can reduce the iron toxicity in two ways. Although, the Fe2+-oxidizing capacity is nullified in the presence of a strong biological reductant like ascorbic acid, this property may play a predominant role during pathogenesis when the cellular ascorbic acid levels deplete significantly. The iron-modulatory property of 1 was also confirmed with the L929 mouse fibroblast cell line.

Keywords: ferrozine assay, Oxidative degradation, intracellular folate pool, Deoxyribose Assay, Iron chelation

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Article Details

Year: 2006
Page: [407 - 413]
Pages: 7
DOI: 10.2174/157340606777724059
Price: $65

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