Novel Fibrinogen Receptor Antagonists - RGDF Mimetics, 4-(1,2,3,4- tetrahydro-isoquinoline-7-yl)amino-4-oxo-butyric Acid Derivatives

Author(s): Sergei A. Andronati, Olga L. Malovichko, Andrei A. Krysko, Tatyana A. Kabanova, Tamara L. Karaseva, Anna S. Petrus

Journal Name: Medicinal Chemistry

Volume 2 , Issue 3 , 2006

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Abstract:

Two novel RGDF mimetics were synthesized with the use of 4-(1,2,3,4-tetrahydro-isoquinoline-7-yl)amino-4- oxo-butyric acid as a new surrogate of Arg-Gly motif. The synthesized compounds have demonstrated a high potency to inhibit platelet aggregation in vitro and to block FITC-Fg binding to αIIbβ3 on washed human platelets.

Keywords: Fibrinogen receptor antagonists, αIIbβ3, GP IIb/IIIa, RGD mimetics, 1,2,3,4-tetrahydro-isoquinoline, platelet aggregation

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Article Details

VOLUME: 2
ISSUE: 3
Year: 2006
Page: [295 - 298]
Pages: 4
DOI: 10.2174/157340606776930817
Price: $65

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