A Radical Route to a cis-3,5-Dialkyl Proline Derivative

Title: A Radical Route to a cis-3,5-Dialkyl Proline Derivative

Volume: 3 Issue: 4

Author(s): Sebastien Guesne, Sebastien Comesse and Catherine Kadouri-Puchot

Affiliation:

Keywords: Amino alcohols, radical cyclization, proline derivative

Abstract: β-Amino alcohols possessing an alkynyl functionality were converted into bicyclic compounds via a 5-exo-dig radical cyclization. One of this bicyclic product was transformed in three steps into the (2R,3S,5S)- 3-methyl-5-iso-propyl proline.

Cite this article as:

Guesne Sebastien, Comesse Sebastien and Kadouri-Puchot Catherine, A Radical Route to a cis-3,5-Dialkyl Proline Derivative, Letters in Organic Chemistry 2006; 3 (4) . https://dx.doi.org/10.2174/157017806776114667