Synthesis and Biological Evaluation of a New Benzofuran Analogue of 8-HETE

Author(s): Pierre Renard, Daniel-Henri Caignard, Catherine Dacquet, Jean Boutin, Pascale Chomarat, Valerie Audinot-Bouchez, Rene Gree, Paul Mosset, Frederic Caijo

Journal Name: Letters in Organic Chemistry

Volume 3 , Issue 2 , 2006

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The total synthesis of a 2,3-disubstituted benzofuran, designed as a structural analogue of a bioactive arachidonic acid metabolite, the 8-(S)-HETE, is reported. This heterocyclic derivative has been evaluated as dual agonist of the PPARα and PPARγ nuclear receptors.

Keywords: 8-HETE, benzofuran, PPARs

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Article Details

Year: 2006
Page: [103 - 106]
Pages: 4
DOI: 10.2174/157017806775224332
Price: $65

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