The Natural Amino Acid Derived Chiral Sulfonamide Ligands in the Catalytic Asymmetric Addition of Phenylacetylene to Aldehydes

Author(s): Zhi-jian Han, Chao-shan Da, Li Qiu, Ming Ni, Yi-feng Zhou, Rui Wang

Journal Name: Letters in Organic Chemistry

Volume 3 , Issue 2 , 2006

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Several simple amino acids derived chiral sulfonamide ligands were synthesized in simple three steps. When we used these ligands in the asymmetric addition of phenylacetylene to aldehydes, the corresponding propargylic alcohols were isolated with good yields. The highest ee value was obtained up to 99%. The results proved that the backbone of the chiral source greatly influenced the enantioselectivity.

Keywords: Sulfonamide alcohol, asymmetric addition, phenylacetylene, aldehyde

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Article Details

Year: 2006
Page: [143 - 148]
Pages: 6
DOI: 10.2174/157017806775224161
Price: $65

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