Green Route to the 2,6-Disubstituted Imidazo[2,1-b]-1,3,4-Thiadiazoles by the Cyclocondensation of α-Bromoacetophenone Derivative and 1,3,4- Thiadiazoles Using Ionic Liquids

Author(s): Mazaahir Kidwai, Shweta Rastogi

Journal Name: Letters in Organic Chemistry

Volume 3 , Issue 2 , 2006


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Abstract:

An eco-friendly facile synthesis of imidazo[2,1-b]-1,3,4-thiadiazoles is described using ionic liquid, [bmim]PF6 (1-butyl-3-methylimidazolium hexafluorophosphate). The use of recyclable catalyst demonstrates the advantages of significant rate enhancement along with improved yields. The protocol is green and effective for producing the desired target moiety.

Keywords: Thiadiazole, ionic liquid, a-bromoacetophenone, imidazo[2,1-b]-1,3,4-, thiadiazoles

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Article Details

VOLUME: 3
ISSUE: 2
Year: 2006
Page: [149 - 152]
Pages: 4
DOI: 10.2174/157017806775224233
Price: $65

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