KF/Al2O3 Mediated Aza-Michael Addition of Indoles to Electron-Deficient Olefins

Author(s): Firouz M. Moghaddam, Ghasem R. Bardajee, Seyedeh M. D. Taimoory

Journal Name: Letters in Organic Chemistry

Volume 3 , Issue 2 , 2006

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KF/Al2O3 efficiently catalyzes aza-Michael addition of indole and 3-methylindole to a variety of electron-deficient conjugated alkenes such as α,β-unsaturated ketones, amides and nitriles. The N-alkylation adducts are produced in good to excellent yields and relatively in short times. The catalyst can be recycled for subsequent reactions without any appreciable loss of efficiency.

Keywords: aza-Michael addition, KF/Al2O3, N-alkylation, Indole, Electron-deficient olefins

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Article Details

Year: 2006
Page: [157 - 160]
Pages: 4
DOI: 10.2174/157017806775224224
Price: $65

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