The present review focuses on the latest development in the synthesis of pyrazolo[3,4-b]pyridines with special accent placed on ring closing methodologies and analysis of diversity of synthons. It also overviews the current green chemistry and multi-component reaction approaches. The major methods and modifications are analyzed.
Keywords: Aminopyrazoles, 3-cyanopyridines, 1,3-dicarbonyl synthons, pyrazolo[3,4-b]pyridines, ring opening reactions, synthesis of pyrazolo[3,4-b]pyridines
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