Characterization of the Self Assembly of Methoxy Poly(Ethylene Oxide)-block-Poly(α-Benzyl Carboxylate-ε-Caprolactone) for the Solubilization and In Vivo Delivery of Valspodar

Author(s): Ziyad Binkhathlan, Sara Elhasi, Dion R. Brocks, Afsaneh Lavasanifar

Journal Name: Current Drug Delivery

Volume 9 , Issue 2 , 2012

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The aim of this study was to characterize the nanostructures formed from assembly of poly(ethylene oxide)-bpoly( α-benzyl carboxylate ε-caprolactone) (PEO-b-PBCL) in water, determine the effect of weight fraction of the hydrophilic block( fEO) on their morphology, and to investigate their potential for solubilization and delivery of P-glycoprotein (P-gp) inhibitor, valspodar. Three PEO-b-PBCL block copolymers having fEO ranging from 0.18-0.40 were synthesized. Assembly of PEO-b-PBCL was triggered through a co-solvent evaporation method. The average critical aggregation concentration (CAC) for PEO114-b-PBCL30, PEO114-b-PBCL60, and PEO114-b-PBCL95 was found to be 62, 41, and 23 nM, respectively. A lower rigidity of the hydrophobic domain in nanostructures formed from the assembly of PEO114-b- PBCL60 and PEO114-b-PBCL95 in comparison to PEO114-b-PBCL30 was observed. The morphology of the assembled structures was characterized by transmission electron microscopy (TEM). The TEM images of PEO114-b-PBCL30 (fEO = 0.40) showed the formation of spherical micelles with high polydispersity, whereas the assembly of PEO114-b-PBCL60 (fEO = 0.25) and PEO114-b-PBCL95 (fEO = 0.18) resulted in a mixed population of spherical micelles and vesicles. Valspodar achieved high loading in all the three PEO-b-PBCL nanocarriers reaching aqueous solubility of nearly 2 mg/mL. The morphology of PEO-b-PBCL carrier did not seem to influence the pharmacokinetics of the encapsulated valspodar in rats following intravenous administration. In conclusion, the results show a potential for PEO-b-PBCL nanocarriers as efficient solubilizing agents for delivery of valspodar.

Keywords: Block coploymers, drug delivery, fluorescence probe, nanostructures, pharmacokinetics, poly(ethylene oxide)-block-poly(ε-caprolactone), polymeric micelle, polymeric vesicle, PSC 833, self-assembly, transmission electron microscopy, valspodar

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Article Details

Year: 2012
Page: [164 - 171]
Pages: 8
DOI: 10.2174/156720112800234512
Price: $65

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