Abstract
Alzheimer disease (AD) is the leading cause of dementia among elderly. Currently, no effective treatment is available for AD. Analysis of transgenic mouse models of AD has facilitated our understanding of disease mechanisms and provided valuable tools for evaluating potential therapeutic strategies. In this review, we will discuss the strengths and weaknesses of current mouse models of AD and the contribution towards understanding the pathological mechanisms and developing effective therapies.
Keywords: Alzheimer disease, amyloid-beta, tau, transgenic mouse models, dementia, neurodegeneration, amyloid precursor protein (APP), mild cognitive impairment (MCI), synaptic dysfunction, mutations
Current Pharmaceutical Design
Title: Transgenic Mouse Models of Alzheimer Disease: Developing a Better Model as a Tool for Therapeutic Interventions
Volume: 18 Issue: 8
Author(s): Masashi Kitazawa, Rodrigo Medeiros and Frank M. LaFerla
Affiliation:
Keywords: Alzheimer disease, amyloid-beta, tau, transgenic mouse models, dementia, neurodegeneration, amyloid precursor protein (APP), mild cognitive impairment (MCI), synaptic dysfunction, mutations
Abstract: Alzheimer disease (AD) is the leading cause of dementia among elderly. Currently, no effective treatment is available for AD. Analysis of transgenic mouse models of AD has facilitated our understanding of disease mechanisms and provided valuable tools for evaluating potential therapeutic strategies. In this review, we will discuss the strengths and weaknesses of current mouse models of AD and the contribution towards understanding the pathological mechanisms and developing effective therapies.
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Cite this article as:
Kitazawa Masashi, Medeiros Rodrigo and M. LaFerla Frank, Transgenic Mouse Models of Alzheimer Disease: Developing a Better Model as a Tool for Therapeutic Interventions, Current Pharmaceutical Design 2012; 18 (8) . https://dx.doi.org/10.2174/138161212799315786
DOI https://dx.doi.org/10.2174/138161212799315786 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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