Adrenomedullin Function in Vascular Endothelial Cells: Insights from Genetic Mouse Models

Author(s): Natalie O. Karpinich, Samantha L. Hoopes, Daniel O. Kechele, Patricia M. Lenhart, Kathleen M. Caron

Journal Name: Current Hypertension Reviews

Volume 7 , Issue 4 , 2011

Become EABM
Become Reviewer
Call for Editor


Adrenomedullin is a highly conserved peptide implicated in a variety of physiological processes ranging from pregnancy and embryonic development to tumor progression. This review highlights past and present studies that have contributed to our current appreciation of the important roles adrenomedullin plays in both normal and disease conditions. We provide a particular emphasis on the functions of adrenomedullin in vascular endothelial cells and how experimental approaches in genetic mouse models have helped to drive the field forward.

Keywords: Adrenomedullin, angiogenesis, endothelial, lymphangiogenesis, mouse model, permeability, CLR, RAMPs, G-protein coupled receptors, transmembrane accessory proteins, vasodilator

open access plus

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2011
Published on: 01 March, 2012
Page: [228 - 239]
Pages: 12
DOI: 10.2174/157340211799304761

Article Metrics

PDF: 48