CD248: Reviewing its Role in Health and Disease

Author(s): Yanet Valdez, Margarida Maia, Edward M. Conway

Journal Name: Current Drug Targets

Volume 13 , Issue 3 , 2012

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CD248, also known as endosialin or tumor endothelial marker-1 (TEM-1), is a C-type lectin-like domain (CTLD) containing cell surface glycoprotein that is expressed by stromal cells of proliferating tissues during embryogenesis and postnatally in tumors and inflammatory lesions. Loss-of-function studies in mice support the notion that CD248 promotes tumor growth and inflammation, observations that are stimulating interest in evaluating this molecule as a therapeutic target. In spite of these advances, the mechanisms by which CD248 modulates cancer and inflammation remain largely enigmatic. This review highlights our current understanding of CD248, its structure, pattern of expression, regulation and function in various disease processes.

Keywords: Cancer, endosialin, fibroblast, inflammation, pericytes, stromal cells, CD248, gene regulation, domain structure, infection

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Article Details

Year: 2012
Page: [432 - 439]
Pages: 8
DOI: 10.2174/138945012799424615
Price: $65

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