CD93: Recent Advances and Implications in Disease

Author(s): Mallary C. Greenlee-Wacker, Manuel D. Galvan, Suzanne S. Bohlson

Journal Name: Current Drug Targets

Volume 13 , Issue 3 , 2012

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While it has been known for some time that CD93 regulates several processes involved in innate immunity and inflammation including phagocytosis and adhesion, the function of CD93 in disease progression is only now being elucidated. Recent in vivo studies in mice, and genome wide studies in mice and humans, have provided clues about its molecular function. Following a comprehensive review of CD93 expression patterns, this review will focus on recent findings over the last three years that address the putative function of CD93 in inflammation and innate immunity.

Keywords: CD93, inflammation, innate immunity, Group XIV, adhesion, AA4.1, MMP cleavage site, microarray studies, ischemia, cancer

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Article Details

Year: 2012
Page: [411 - 420]
Pages: 10
DOI: 10.2174/138945012799424651
Price: $65

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