Identification and Functional Study of Cytokines and Chemokines Involved in Tumorigenesis

Author(s): Jun Zeng, Ke Xie, Hong Wu, Boya Zhang, Canhua Huang

Journal Name: Combinatorial Chemistry & High Throughput Screening
Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research

Volume 15 , Issue 3 , 2012

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Tumorigenesis may be affected by various cellular components in the tumor cells and/or by tumor microenvironmental factors. Cytokines, including chemokines (chemotactic cytokines) are polypeptides or small soluble proteins generated by leukocytes and non-leukocytes, including cancer cells and stromal cells, for example, fibroblasts, mesenchymal stem cells (MSCs) and epithelial cells. Cytokines exert their functions on the cells that secrete them, on nearby cells, or on distant cells. Chemokines have expanded beyond their initial roles in impinging on every aspect of the immune system and leukocyte biology. They display multifunctional effects for regulating angiogenesis, tumor cell proliferation and apoptosis, mediating tumor cell metastasis in an organ-specific manner. This review will focus on the structural and functional aspects of chemokines as well as the roles that cytokines and their receptors play in angiogenesis, tumor invasion and metastasis, and discuss their potential value as important therapeutic targets for intervention in cancer.

Keywords: Angiogenesis, chemokines, cytokines, invasion, metastasis, tumorigenesis, microenvironmental factors, polypeptides, stromal cells, tumor cell growth, specific cells, immnue system, transmembrane receptors, cellular transformation, endothelium, cancer-associated fibroblasts, G-protein coupled receptors, inflammation, pathogen infection, T lymphocytes, GDP, GTP, cell invasion, migration, extracellular-regulated kinase

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Article Details

Year: 2012
Page: [276 - 285]
Pages: 10
DOI: 10.2174/138620712799218608
Price: $65

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