Advent of the Cancer Methylome

Author(s): Huey Shan Nai, Quek Choon Lau

Journal Name: Combinatorial Chemistry & High Throughput Screening
Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research

Volume 15 , Issue 3 , 2012

Become EABM
Become Reviewer


DNA hypermethylation of CpG islands plays an important role in gene regulation during cancer development. Many techniques have been developed to detect global DNA methylation in cancer cells compared to normal tissues. This knowledge helps us to better understand cancer progression and also aids in the development of new biomarker for early cancer detection. New prognostic tools for monitoring drug efficacy during cancer treatment can also be developed. In this review, we will examine the different techniques that have been used to study DNA methylation, as well as the emerging high resolution, high throughput techniques for identification of methylated regions to defining cancer related genes in the cancer methylome.

Keywords: Biomarker, cancer, CpG islands, DNA methylation, epigenome, methylome, tumor suppressor gene, gene expression, histone, DNA sequence, cytosine, immunoprecipitation, X-linked imprinting, detection, chemotherapy, isoschizomers, restriction enzymes, disgested fragments, carcinoma, MS-AP-PCR

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2012
Page: [216 - 220]
Pages: 5
DOI: 10.2174/138620712799218590
Price: $65

Article Metrics

PDF: 4