Basic Symptoms and the Prediction of First-Episode Psychosis

Author(s): Frauke Schultze-Lutter, Stephan Ruhrmann, Paolo Fusar-Poli, Andreas Bechdolf, Benno G. Schimmelmann, Joachim Klosterkotter

Journal Name: Current Pharmaceutical Design

Volume 18 , Issue 4 , 2012

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Recent focus on early detection and intervention in psychosis has renewed interest in subtle psychopathology beyond positive and negative symptoms. Such self-experienced sub-clinical disturbances are described in detail by the basic symptom concept. This review will give an introduction into the concept of basic symptoms and describe the development of the current instruments for their assessment, the Schizophrenia Proneness Instrument, Adult (SPI-A) and Child and Youth version (SPI-CY), as well as of the two at-risk criteria: the at-risk criterion Cognitive-Perceptive Basic Symptoms (COPER) and the high-risk criterion Cognitive Disturbances (COGDIS). Further, an overview of prospective studies using both or either basic symptom criteria and transition rates related to these will be given, and the potential benefit of combining ultra-high risk criteria, particularly attenuated psychotic symptoms, and basic symptom criteria will be discussed. Finally, their prevalence in psychosis patients, i.e. the sensitivity, as well as in general population samples will be described. It is concluded that both COPER and COGDIS are able to identify subjects at a high risk of developing psychosis. Further, they appear to be sufficiently frequent prior to onset of the first psychotic episode as well as sufficiently rare in persons of general population to be considered as valuable for an early detection of psychosis.

Keywords: Psychosis, prediction, early detection, basic symptoms, COGDIS, COPER, Schizophrenia Proneness Instrument, climacteric period, frank psychosis, Spearman's rank correlation

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Article Details

Year: 2012
Published on: 01 March, 2012
Page: [351 - 357]
Pages: 7
DOI: 10.2174/138161212799316064
Price: $65

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