Title: The Chlorophyll Catabolite Pheophorbide a as a Photosensitizer for the Photodynamic Therapy
VOLUME: 19 ISSUE: 6
Author(s):L. E. Xodo, V. Rapozzi, M. Zacchigna, S. Drioli and S. Zorzet
Affiliation:Department of Medical and Biological Sciences, P.le Kolbe 4, School of Medicine, 33100 Udine, Italy.
Keywords:Photodynamic therapy, Pheophorbide a, Photophysical parameters, Tissue distribution, Imaging, In vivo activity, clorophyll, phototoxicity, PDT activity, photochemical reaction
Abstract: Pheophorbide a is a clorophyll catabolite that recently has drawn the attention of several investigators for its potential in photodynamic therapy. In this review we summarize its photophysical properties, phototoxicity, cellular localization, biodistribution and PDT activity as a free or conjugated molecule.
