Transition-Metal-Free Catalysts for the Sustainable Epoxidation of Alkenes: From Discovery to Optimisation by Means of High Throughput Experimentation

Author(s): Warunee Lueangchaichaweng, Inge Geukens, Annelies Peeters, Benjamin Jarry, Franck Launay, Jean-Luc Bonardet, Pierre A. Jacobs, Paolo P. Pescarmona

Journal Name: Combinatorial Chemistry & High Throughput Screening
Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research

Volume 15 , Issue 2 , 2012

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Abstract:

Transition-metal-free oxides were studied as heterogeneous catalysts for the sustainable epoxidation of alkenes with aqueous H2O2 by means of high throughput experimentation (HTE) techniques. A full-factorial HTE approach was applied in the various stages of the development of the catalysts: the synthesis of the materials, their screening as heterogeneous catalysts in liquid-phase epoxidation and the optimisation of the reaction conditions. Initially, the chemical composition of transition-metal-free oxides was screened, leading to the discovery of gallium oxide as a novel, active and selective epoxidation catalyst. On the basis of these results, the research line was continued with the study of structured porous aluminosilicates, gallosilicates and silica-gallia composites. In general, the gallium-based materials showed the best catalytic performances. This family of materials represents a promising class of heterogeneous catalysts for the sustainable epoxidation of alkenes and offers a valid alternative to the transition-metal heterogeneous catalysts commonly used in epoxidation. High throughput experimentation played an important role in promoting the development of these catalytic systems.

Keywords: Gallium oxide, Al-SBA-15, Ga-SBA-15, sustainable epoxidation, full-factorial, heterogeneous catalysts, high throughput experimentation, energy, environment, conversion, renewable resources, high turnover, toxic substances, substrates, chemical composition, alkenes, time-consuming, liquid-phase reactions, gas chromatograph, epoxides, precursors, deactivation, isomorphous, microporous

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Article Details

VOLUME: 15
ISSUE: 2
Year: 2012
Page: [140 - 151]
Pages: 12
DOI: 10.2174/138620712798868338
Price: $65

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