Sunflower Trypsin Inhibitor 1 as a Molecular Scaffold for Drug Discovery

Author(s): Adam Lesner, Anna Legowska, Magdalena Wysocka, Krzysztof Rolka

Journal Name: Current Pharmaceutical Design

Volume 17 , Issue 38 , 2011

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This work is focused on SFTI-1, a member of the Bowman-Birk family of inhibitors. This 14 amino acid cyclic peptide exhibits several features i.e. compact rigidity, well-defined structure and small size that could result in a wide range of potential applications. Some examples of engineering of the specificity of this inhibitor along with structure - activity relationships will be discussed herein. Additionally, potential uses of STFI-1 and its analogs as pharmaceutical agents will be described.

Keywords: SFTI-1, inhibitor, serine proteinases, peptidomimetics, peptomers, analogs, pharmaceutical agents, cytotoxicity, trypsin, chymotrypsin

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Article Details

Year: 2011
Page: [4308 - 4317]
Pages: 10
DOI: 10.2174/138161211798999393
Price: $65

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