This work is focused on SFTI-1, a member of the Bowman-Birk family of inhibitors. This 14 amino acid cyclic peptide exhibits several features i.e. compact rigidity, well-defined structure and small size that could result in a wide range of potential applications. Some examples of engineering of the specificity of this inhibitor along with structure - activity relationships will be discussed herein. Additionally, potential uses of STFI-1 and its analogs as pharmaceutical agents will be described.
Keywords: SFTI-1, inhibitor, serine proteinases, peptidomimetics, peptomers, analogs, pharmaceutical agents, cytotoxicity, trypsin, chymotrypsin
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