The Role of T and B Cells in Atherosclerosis: Potential Clinical Implications

Author(s): I. E. Dumitriu, J. C. Kaski

Journal Name: Current Pharmaceutical Design

Volume 17 , Issue 37 , 2011

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The chronic inflammation process that characterises atherosclerosis involves both the innate and adaptive arms of the immune system. Several lines of evidence have recently highlighted pivotal roles for T and B lymphocytes – cells that belong to the adaptive immune system – in the development and progression of atherosclerosis. In this review, we summarise the current knowledge on the roles of adaptive immune responses in atherosclerosis and present our views on how a better understanding of these immune mechanisms could shape future therapies to slow down or even prevent this disease.

Keywords: Adaptive immune response, T cells, B cells, atherosclerosis, metallo-proteinases (MMPs), acute coronary syndrome (ACS), macrophages, monoclonal antibody, rheumatoid arthritis, systemic lupus erythematosus

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Article Details

Year: 2011
Page: [4159 - 4171]
Pages: 13
DOI: 10.2174/138161211798764834
Price: $65

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PDF: 12