New Insights into Redox-Modulated Cell Signaling

Author(s): Gabriella Leonarduzzi, Barbara Sottero, Gabriella Gabriella Testa, Fiorella Biasi, Giuseppe Poli

Journal Name: Current Pharmaceutical Design

Volume 17 , Issue 36 , 2011

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The complex system of molecular communications underlying cell biochemistry and function involves numerous components including kinases, phosphatases and transcription factors, which are known to be sensitive to cellular and tissue redox changes. Reactive oxygen species (ROS), whose constitutive generation in cells and tissues is amplified under pro-oxidant conditions, are now unanimously recognized to be important triggers and modulators of cell signaling, and consequently of cell behavior. This review considers the major signaling pathways that mediate gene regulation in response to ROS.

Keywords: Reactive oxygen species, oxidative stress, cell signaling, kinases, phosphatases, transcription factors, urokinase plasminogen activator, Arachidonic acid, tumorigenesis, H2O2

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Article Details

Year: 2011
Page: [3994 - 4006]
Pages: 13
DOI: 10.2174/138161211798764906
Price: $65

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PDF: 16