The Hedgehog Knows Many Tricks

Author(s): Glen J. Weiss, Alain C. Mita, Daniel D. Von Hoff

Journal Name: Current Drug Targets

Volume 12 , Issue 14 , 2011

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Contrary to the Classical Greek poet Archilochus phrase “The fox knows many things but the hedgehog knows one big thing”, the Hedgehog (HH) signaling pathway knows at least 3 ways to promote or support carcinogenesis. In this review, we provide a summary of the HH signaling pathway, and detail the clinical relevance and treatment of patients. Finally, future directions in exploiting this promising pathway will be addressed.

Keywords: Hedgehog pathway, cancer, treatment, mutation, autocrine, paracrine, signaling, clinical trial, carcinogenesis, PTCH1

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Article Details

Year: 2011
Page: [2091 - 2095]
Pages: 5
DOI: 10.2174/138945011798829429
Price: $65

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