Title: Therapeutic Interventions Targeting Beta Amyloid Pathogenesis in an Aging Dog Model
VOLUME: 9 ISSUE: 4
Author(s):Sarah B. Martin, Amy L.S. Dowling and Elizabeth Head
Affiliation:Sanders Brown Center on Aging, University of Kentucky, Lexington KY, USA.
Keywords:Alzheimer's disease, canine, statins, BACE-1 inhibitors, metal-chelators, A-beta vaccination
Abstract: Aged dogs and humans share complex cognitive and pathological responses to aging. Specifically, dogs develop Alzheimers Disease (AD) like beta-amyloid (Aβ) that are associated with cognitive deficits. Currently, therapeutic approaches to prevent AD are targeted towards reduced production, aggregation and increased clearance of Aβ. The current review discusses cognition and neuropathology of the aging canine model and how it has and continues to be useful in further understanding the safety and efficacy of potential AD prevention therapies targeting A
