Abstract
It is well known that legumes, especially soybeans, are beneficial to health due to the presence of saponins and an abundance of fiber and proteins. Defensins and other related defense proteins with antifungal activity in legumes act against fungi which are human pathogens and also against phytopathogenic fungi. These proteins exhibit HIV-1 reverse transcriptase inhibitory and antitumor activities. Some of these proteins have remarkable stability to proteases, and changes in pH and temperature and are promising therapeutic candidates.
Keywords: Defensins, beans, biocidal proteins, bean seeds, medicinal activity, antifungal, HIV-1 reverse transcriptase inhibitory activity, antitumor activity, phytopathogenic fungi, antitumor activities
Current Medicinal Chemistry
Title: Defensins and Other Biocidal Proteins from Bean Seeds with Medicinal Activities
Volume: 18 Issue: 36
Author(s): T. B. Ng, J. H. Wong and E. F. Fang
Affiliation:
Keywords: Defensins, beans, biocidal proteins, bean seeds, medicinal activity, antifungal, HIV-1 reverse transcriptase inhibitory activity, antitumor activity, phytopathogenic fungi, antitumor activities
Abstract: It is well known that legumes, especially soybeans, are beneficial to health due to the presence of saponins and an abundance of fiber and proteins. Defensins and other related defense proteins with antifungal activity in legumes act against fungi which are human pathogens and also against phytopathogenic fungi. These proteins exhibit HIV-1 reverse transcriptase inhibitory and antitumor activities. Some of these proteins have remarkable stability to proteases, and changes in pH and temperature and are promising therapeutic candidates.
Export Options
About this article
Cite this article as:
B. Ng T., H. Wong J. and F. Fang E., Defensins and Other Biocidal Proteins from Bean Seeds with Medicinal Activities, Current Medicinal Chemistry 2011; 18 (36) . https://dx.doi.org/10.2174/092986711798347306
DOI https://dx.doi.org/10.2174/092986711798347306 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
Call for Papers in Thematic Issues
Advances in Medicinal Chemistry: From Cancer to Chronic Diseases.
The broad spectrum of the issue will provide a comprehensive overview of emerging trends, novel therapeutic interventions, and translational insights that impact modern medicine. The primary focus will be diseases of global concern, including cancer, chronic pain, metabolic disorders, and autoimmune conditions, providing a broad overview of the advancements in ...read more
Approaches to the treatment of chronic inflammation
Chronic inflammation is a hallmark of numerous diseases, significantly impacting global health. Although chronic inflammation is a hot topic, not much has been written about approaches to its treatment. This thematic issue aims to showcase the latest advancements in chronic inflammation treatment and foster discussion on future directions in this ...read more
Cellular and Molecular Mechanisms of Non-Infectious Inflammatory Diseases: Focus on Clinical Implications
The Special Issue covers the results of the studies on cellular and molecular mechanisms of non-infectious inflammatory diseases, in particular, autoimmune rheumatic diseases, atherosclerotic cardiovascular disease and other age-related disorders such as type II diabetes, cancer, neurodegenerative disorders, etc. Review and research articles as well as methodology papers that summarize ...read more
Chalcogen-modified nucleic acid analogues
Chalcogen-modified nucleosides, nucleotides and oligonucleotides have been of great interest to scientific research for many years. The replacement of oxygen in the nucleobase, sugar or phosphate backbone by chalcogen atoms (sulfur, selenium, tellurium) gives these biomolecules unique properties resulting from their altered physical and chemical properties. The continuing interest in ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Genetic Markers of Osteoarthritis
Current Rheumatology Reviews Astrocytic α7 Nicotinic Receptor Activation Inhibits Amyloid-β Aggregation by Upregulating Endogenous αB-crystallin through the PI3K/Akt Signaling Pathway
Current Alzheimer Research Lymphangiogenesis and Anti-Tumor Immune Responses
Current Molecular Medicine Folic acid Targeted Polymeric Micelles Based on Tocopherol Succinate- Pulluan as an Effective Carrier for Epirubicin: Preparation, Characterization and In-vitro Cytotoxicity Assessment
Current Drug Delivery Predictors and Clinical Implications of HPV Reservoire Districts for Genital Tract Disease
Current Pharmaceutical Design Nanomedicine as a Strategy for Natural Compound Delivery to Prevent and Treat Cancers
Current Pharmaceutical Design Clinical Evidence of Herb-Drug Interactions: A Systematic Review by the Natural Standard Research Collaboration
Current Drug Metabolism Application of Electroporation in DNA Vaccination Protocols
Current Gene Therapy Cell Cycle Regulatory Protein 5 (Cdk5) is a Novel Downstream Target of ERK in Carboplatin Induced Death of Breast Cancer Cells (Supplementary Data)
Current Cancer Drug Targets Recent Advances of Natural and Synthetic β-Carbolines as Anticancer Agents
Anti-Cancer Agents in Medicinal Chemistry Eliminating Ovarian Cancer Stem Cells: A Potential Therapeutic Target for Ovarian Cancer Chemoresistance
Current Protein & Peptide Science Cancer Gene Therapy through Autonomous Parvovirus - Mediated Gene Transfer
Current Gene Therapy Specific Targeting of Engineered Nanoparticles to Activated Macrophages
Current Nanoscience Animal Mitochondria: Evolution, Function, and Disease
Current Molecular Medicine Emerging Therapies in Relapsing-Remitting Multiple Sclerosis
Reviews on Recent Clinical Trials Exploration of Chemopreventive Potential of Linalool in Targeting Lung Cancer Biomarkers
Endocrine, Metabolic & Immune Disorders - Drug Targets Quality, not Quantity: The Role of Natural Products and Chemical Proteomics in Modern Drug Discovery
Combinatorial Chemistry & High Throughput Screening Spatio-Temporal Expression and Functional Analysis of miR-206 in Developing Orofacial Tissue
MicroRNA Fertility Preservation in Women After the Cancer
Current Pharmaceutical Design Somatostatin Receptor-Targeted Anti-Cancer Therapy
Current Drug Delivery