Green Synthesis of Tetrahydrobenzo[b]Pyrans by Microwave Assisted Multi-Component One-Pot Reactions in PEG-400

Author(s): Chun Feng, Qiuyan Wang, Cuifen Lu, Guichun Yang, Zuxing Chen

Journal Name: Combinatorial Chemistry & High Throughput Screening
Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research

Volume 15 , Issue 1 , 2012

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Polyethylene glycol is found to be a nontoxic and recyclable reaction medium for the microwave-assisted, multi-component one-pot reactions of aromatic aldehydes with ethyl-2-cyanoacetate and 1,3-cyclohexanedione or 5,5- dimethyl-1,3-cyclohexanedione in the presence of piperidine. This environmentally friendly microwave protocol offers ease of operation and enables recyclability of reaction medium and synthesis of a variety of substituted tetrahydrobenzo[b]pyran derivatives. It is an efficient, promising, and green synthetic strategy to construct tetrahydrobenzo[b]pyran skeleton.

Keywords: Microwave assisted, multi-component, one-pot reaction, PEG-400, Tetrahydrobenzo[b]pyrans, Polyethylene glycol, nontoxic, recyclable reaction, green synthetic strategy, solvent-free syntheses, organic reactions, pharmacological properties

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Article Details

Year: 2012
Page: [100 - 103]
Pages: 4
DOI: 10.2174/138620712798280790

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