The 7-oxabicyclo[2.2.1]heptene ring system is a common structural motif in many pharmacologically interesting molecules. We recognized the potential to employ this highly oxygenated and conformationally-restricted scaffold in diversity-oriented synthesis to generate a library of non-chiral but topologically complex compounds. Herein, we report the synthesis and biological evaluation of two 96-member tricyclic libraries containing the oxabicyclo[2.2.1]heptene framework using acetal formation as the key step.
Keywords: Acetal, Antibacterial, oxabicyclo[2.2.1]heptene, Natural products, drug discovery, complex compounds, biologically active molecules, column purification, Antifungal Assays, antibiotics, combinatorial libraries, receptor
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