Pro-Inflammatory Cytokines and their Actions on the Metabolic Disturbances Associated with Cancer: Implications in Cachexia

Author(s): Josep M. Argiles, Miriam Toledo, Francisco J. Lopez-Soriano, Silvia Busquets

Journal Name: Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
(Formerly Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents)

Volume 10 , Issue 4 , 2011

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The main aim of the present review is to summarize and evaluate the different molecular mechanisms and catabolic mediators (mainly cytokines) involved in cancer cachexia since they may represent targets for future promising clinical investigations.

Keywords: TNF-, IL-6, IL-1, TWEAK, myostatin, PIF, transcriptional factors, cancer cachexia, anorexia

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Article Details

Year: 2011
Page: [275 - 280]
Pages: 6
DOI: 10.2174/187152311797928199
Price: $65

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