Abstract
Hypertension is increasingly considered a strong and independent risk factor for supraventricular and ventricular arrhythmias. The presence and complexity of both supraventricular and ventricular arrhythmias influence morbidity, mortality, as well as the quality of life of patients. Diastolic dysfunction of the left ventricle, left atrial size and function, and left ventricular hypertrophy have been suggested as the foremost underlying risk factors for supraventricular and ventricular arrhythmias in hypertensive patients. In particular, the presence of hypertension is a risk for sudden death and this risk is higher in those with left ventricular hypertrophy. Moreover, arrhythmias in the hypertrophic heart are often facilitated and aggravated by electrolyte disturbances, sympatho-vagal unbalance, transient blood pressure peaks, and occurrence of myocardial ischaemia.
Several noninvasive biohumoral, electrocardiographic and imaging parameters have been widely investigated to identify hypertensive patients at higher risk for the development of arrhythmias. These parameters include neurohormones, signal averaged analysis of P wave, QT interval dispersion, heart rate variability, ventricular late potentials and T wave morphology analysis, as well as echocardiographic and magnetic resonance indexes of atrial and ventricular shape and function. The aim of this review is to evaluate the relationship of high blood pressure with ventricular and supraventricular arrhythmias, to discuss the available biomarkers for arrhythmic risk assessment in hypertensive patients and the effects of a tailored tight blood pressure control on the occurrence of arrhythmias.
Keywords: Hypertension, ventricular hypertrophy, arrhythmia, tachycardia, sudden death, atrial fibrillation, refractoriness, fibrosis, myocardial ischaemia, Echocardiography
Current Pharmaceutical Design
Title: Markers of Arrhythmogenic Risk in Hypertensive Subjects
Volume: 17 Issue: 28
Author(s): Andrea Barison, Giuseppe Vergaro, Luigi Emilio Pastormerlo, Lorenzo Ghiadoni, Michele Emdin and Claudio Passino
Affiliation:
Keywords: Hypertension, ventricular hypertrophy, arrhythmia, tachycardia, sudden death, atrial fibrillation, refractoriness, fibrosis, myocardial ischaemia, Echocardiography
Abstract: Hypertension is increasingly considered a strong and independent risk factor for supraventricular and ventricular arrhythmias. The presence and complexity of both supraventricular and ventricular arrhythmias influence morbidity, mortality, as well as the quality of life of patients. Diastolic dysfunction of the left ventricle, left atrial size and function, and left ventricular hypertrophy have been suggested as the foremost underlying risk factors for supraventricular and ventricular arrhythmias in hypertensive patients. In particular, the presence of hypertension is a risk for sudden death and this risk is higher in those with left ventricular hypertrophy. Moreover, arrhythmias in the hypertrophic heart are often facilitated and aggravated by electrolyte disturbances, sympatho-vagal unbalance, transient blood pressure peaks, and occurrence of myocardial ischaemia.
Several noninvasive biohumoral, electrocardiographic and imaging parameters have been widely investigated to identify hypertensive patients at higher risk for the development of arrhythmias. These parameters include neurohormones, signal averaged analysis of P wave, QT interval dispersion, heart rate variability, ventricular late potentials and T wave morphology analysis, as well as echocardiographic and magnetic resonance indexes of atrial and ventricular shape and function. The aim of this review is to evaluate the relationship of high blood pressure with ventricular and supraventricular arrhythmias, to discuss the available biomarkers for arrhythmic risk assessment in hypertensive patients and the effects of a tailored tight blood pressure control on the occurrence of arrhythmias.
Export Options
About this article
Cite this article as:
Barison Andrea, Vergaro Giuseppe, Emilio Pastormerlo Luigi, Ghiadoni Lorenzo, Emdin Michele and Passino Claudio, Markers of Arrhythmogenic Risk in Hypertensive Subjects, Current Pharmaceutical Design 2011; 17 (28) . https://dx.doi.org/10.2174/138161211798157748
DOI https://dx.doi.org/10.2174/138161211798157748 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
Call for Papers in Thematic Issues
"Tuberculosis Prevention, Diagnosis and Drug Discovery"
The Nobel Prize-winning discoveries of Mycobacterium tuberculosis and streptomycin have enabled an appropriate diagnosis and an effective treatment of tuberculosis (TB). Since then, many newer diagnosis methods and drugs have been saving millions of lives. Despite advances in the past, TB is still a leading cause of infectious disease mortality ...read more
Current Pharmaceutical challenges in the treatment and diagnosis of neurological dysfunctions
Neurological dysfunctions (MND, ALS, MS, PD, AD, HD, ALS, Autism, OCD etc..) present significant challenges in both diagnosis and treatment, often necessitating innovative approaches and therapeutic interventions. This thematic issue aims to explore the current pharmaceutical landscape surrounding neurological disorders, shedding light on the challenges faced by researchers, clinicians, and ...read more
Emerging and re-emerging diseases
Faced with a possible endemic situation of COVID-19, the world has experienced two important phenomena, the emergence of new infectious diseases and/or the resurgence of previously eradicated infectious diseases. Furthermore, the geographic distribution of such diseases has also undergone changes. This context, in turn, may have a strong relationship with ...read more
Melanoma and Non-Melanoma Skin Cancer Treatment: Standard of Care and Recent Advances
In this thematic issue, we aim to provide a standard of care of the diagnosis and treatment of melanoma and non-melanoma skin cancer. The editor will invite authors from different countries who will write review articles of melanoma and non-melanoma skin cancers. The Diagnosis, Staging, Surgical Treatment, Non-Surgical Treatment all ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Microparticles as Biomarkers of Vascular Dysfunction in Metabolic Syndrome and its Individual Components
Current Vascular Pharmacology Ezetimibe and Vascular Inflammation
Current Vascular Pharmacology VDAC-Targeted Drugs Affecting Cytoprotection and Mitochondrial Physiology in Cerebrovascular and Cardiovascular Diseases
Current Medicinal Chemistry Diet and Heart Health: Moderate Wine Drinking Strengthens the Cardioprotective Effects of Fish Consumption
Current Pharmaceutical Biotechnology Isolated Perioperative Hypertension: Clinical Implications & Contemporary Treatment Strategies
Current Hypertension Reviews Nonalcoholic Fatty Liver Disease (NAFLD) for Primary Care Providers: Beyond the Liver
Current Hypertension Reviews Statin Treatment Non-adherence and Discontinuation: Clinical Implications and Potential Solutions
Current Pharmaceutical Design Dietary Patterns in Alzheimers Disease and Cognitive Aging
Current Alzheimer Research Aldosterone, From (Patho)Physiology to Treatment in Cardiovascular and Renal Damage
Current Vascular Pharmacology Statin Treatment and the Natural History of Atherosclerotic-Related Diseases: Pathogenic Mechanisms and the Risk-Benefit Profile
Current Pharmaceutical Design Impact of Jugular Vein Valve Function on Cerebral Venous Haemodynamics
Current Neurovascular Research Recent Developments in Studies of l-Stepholidine and its Analogs: Chemistry, Pharmacology and Clinical Implications
Current Medicinal Chemistry Impact of Cardiovascular Factors on Pulse Wave Velocity and Total Vascular Resistance in Different Age Group Patients with Cardiovascular Disorders
Current Aging Science Cardiovascular Disease in Masked Hypertension: Clinical Implications
Current Hypertension Reviews Urinary Steroids Measured by Modern Separation Techniques and Applied as Biomarkers in Stress Studies
Current Pharmaceutical Analysis Diabetes-Induced Alterations in Renal Medullary Microcirculation and Metabolism
Current Diabetes Reviews Discovery of Potent, Non-Steroidal and Highly Selective Glucocorticoid Receptor Antagonists with Anti-Obesity Activity
Letters in Drug Design & Discovery Editorial: Optimizing Chronic Heart Failure Care Beyond Randomised Controlled Trials – What are the problem areas and potential solutions?
Current Cardiology Reviews Hyperpolarized Metabolic MR in the Study of Cardiac Function and Disease
Current Pharmaceutical Design Primary and Secondary Hypertriglyceridaemia
Current Drug Targets