Chromenopyridines: Promising Scaffolds for Medicinal and Biological Chemistry

Author(s): L. J. Nunez-Vergara, J. A. Squella, P. A. Navarrete-Encina, E. Vicente-Garcia, S. Preciado, R. Lavilla

Journal Name: Current Medicinal Chemistry

Volume 18 , Issue 31 , 2011

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Chromenopyridines constitute a structurally diverse class of compounds with a wide range of bioactivities and increasing presence in drugs. Here we analyze the scope of the synthetic methodology to access this nucleus with emphasis on multicomponent reactions and robust methodologies. Reactivity issues, medicinal applications and other properties are also reviewed.

Keywords: Azines, benzopyran, chromene, coumarin, drug-like scaffolds, heterocycles, multicomponent reactions, privileged structures, pyridine, synthetic methods

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Article Details

Year: 2011
Page: [4761 - 4785]
Pages: 25
DOI: 10.2174/092986711797535272
Price: $65

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