Recent Advance in Aminopeptidase N (APN/CD13) Inhibitor Research

Author(s): X. Zhang, H. Fang, J. Zhang, Y. Yuan, W. Xu

Journal Name: Current Medicinal Chemistry

Volume 18 , Issue 32 , 2011

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Abstract:

APN is an important zinc dependent metallo-exopeptidase, which can degrade the extracellular matrix, and plays an important role in tumor invasion, metastasis and angiogenesis. it has been considered as a suitable target for anti-cancer drug design. Recently, research of structure-based APN inhibitors is becoming an interesting field, and many APN inhibitors have been reported. Here we review a series of APN inhibitors and the recent progress in this field.

Keywords: Aminopeptidase N, rational drug design, inhibitors, peptidomimetics, anti-tumor, structure activity relationship

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Article Details

VOLUME: 18
ISSUE: 32
Year: 2011
Page: [5011 - 5021]
Pages: 11
DOI: 10.2174/092986711797535155
Price: $65

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