Alkaloids and Flavonoids as α1-Adrenergic Receptor Antagonists

Author(s): W. Li, L. Du, M. Li

Journal Name: Current Medicinal Chemistry

Volume 18 , Issue 32 , 2011

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Abstract:

Since the subtypes of α1-adrenergic receptor have been thoroughly determined, to date medicinal chemists raise their deliberation on how to conceive selective α1-adrenergic receptor antagonist with the minimal side effects. It needs to be well recognized that natural products can exist as a significant source of drug leads, thus portraying a consequential capacity in drug design and development. The current review article would like to present a comprehensive survey on natural products, mainly including alkaloids and flavonoids, which exhibit α1-adrenergic receptor antagonistic activities.

Keywords: α1-adrenergic receptor, antagonist, natural products, alkaloids, flavonoids, homologous GPCRs, vasodilatation, transmembrane domains, G proteins, pharmacological properties

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Article Details

VOLUME: 18
ISSUE: 32
Year: 2011
Page: [4923 - 4932]
Pages: 10
DOI: 10.2174/092986711797535209
Price: $65

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