Since the subtypes of α1-adrenergic receptor have been thoroughly determined, to date medicinal chemists raise their deliberation on how to conceive selective α1-adrenergic receptor antagonist with the minimal side effects. It needs to be well recognized that natural products can exist as a significant source of drug leads, thus portraying a consequential capacity in drug design and development. The current review article would like to present a comprehensive survey on natural products, mainly including alkaloids and flavonoids, which exhibit α1-adrenergic receptor antagonistic activities.
Keywords: α1-adrenergic receptor, antagonist, natural products, alkaloids, flavonoids, homologous GPCRs, vasodilatation, transmembrane domains, G proteins, pharmacological properties
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