Cyclodextrins Based Enantioselective, Potentiometric Membrane Electrodes (EPME) and their Applications for Enantioanalysis of L-Cysteine in Urine

Author(s): Raluca-Ioana Stefan-van Staden, Luxolo Holo, Jacobus F. van Staden

Journal Name: Current Pharmaceutical Analysis

Volume 7 , Issue 4 , 2011


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Abstract:

Four enantioselective, potentiometric membrane electrodes based on carbon paste impregnated with α-, β-, 2- hydroxyl-3-trimethylammoniopropyl -β- (as chloride salt) and γ-cyclodextrins are proposed for the enantioanalysis of Lcysteine. The proposed electrodes exhibited near-Nernstian slopes in a wide linear concentration range: 10-10 - 10-3 mol/L, with very low detection limits, near 10-11 mol/L. The surfaces of the electrodes are easily renewable by simply polishing on an alumina paper.

Keywords: L-cysteine, Cyclodextrin, Direct potentiometry, Enantioanalysis, Potentiometric Selectivity Coefficient, PVP, D-Cys, Liquid chromatography, Chemiluminescence, Capillary electrophoresis

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Article Details

VOLUME: 7
ISSUE: 4
Year: 2011
Page: [258 - 261]
Pages: 4
DOI: 10.2174/157341211797457998
Price: $65

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