Enantioselective, Potentiometric Membrane Electrodes (EPME) Based on Maltodextrins for the Determination of L-Vesamicol in Serum Samples

Author(s): Raluca-Ioana Stefan-van Staden, R'afat M. Nejem, Jacobus F. van Staden, Hassan Y. Aboul-Enein

Journal Name: Current Pharmaceutical Analysis

Volume 7 , Issue 4 , 2011


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Abstract:

Three EPMEs based on maltodextrins with different dextrose equivalent (DE) values [I (4.0-7.0), II (13.0-17.0) and III (16.5-19.5)], were designed for the determination of L-vesamicol. The linear concentration ranges of the proposed electrodes were 10-4 - 10-2 mol/L for maltodextrin I-based electrode, 10-5 -10-3 mol/L for maltodextrin II-based electrode and 10-9 - 10-7 mol/L for maltodextrin III-based electrode. The detection limits of the proposed electrodes were 1.34x10-5, 5.0x10-6 and 3.33x10-10 mol/L for maltodextrin I, II and III based electrodes, respectively. The selectivity of EPMEs for L-vesamicol was tested over D-vesamicol, creatine, creatinine and some inorganic ions. The surfaces of the electrodes can be easily renewed by simply polishing on alumina.

Keywords: Enantioselective, Potentiometric membrane electrode, Maltodextrins, L-vesamicol, Alzheimer's disease, Ag/AgCl electrode, Parkinson's disease, Down's Syndrome, Olivopontocerebellar atrophy, Electrophoresis

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Article Details

VOLUME: 7
ISSUE: 4
Year: 2011
Page: [253 - 257]
Pages: 5
DOI: 10.2174/157341211797458069
Price: $65

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