Blood-Brain Barrier P-Glycoprotein Function in Neurodegenerative Disease

Author(s): A.L. Bartels

Journal Name: Current Pharmaceutical Design

Volume 17 , Issue 26 , 2011

Become EABM
Become Reviewer
Call for Editor


Protection of the brain is strengthened by active transport and ABC transporters. P-glycoprotein (P-gp) at the blood-brain barrier (BBB) functions as an active efflux pump by extruding a substrate from the brain, which is important for maintaining loco-regional homeostasis in the brain and protection against toxic compounds. Importantly, dysfunctional BBB P-gp transport is postulated as an important factor contributing to accumulation of aggregated protein in neurodegenerative disorders such as Alzheimers disease (AD) and Parkinsons disease (PD). Furthermore, P-gp is a major factor in mediating resistance to brain entry of numerous exogenous compounds, including toxins that can be involved in PD pathogenesis. This review highlights the role of altered P-gp function in the pathogenesis and progression of neurodegenerative disease. Also the implications of alterations in P-gp function for the treatment of these diseases are discussed.

Keywords: Blood-brain barrier, P-glycoprotein, [11C]-verapamil PET, Parkinson, Alzheimer, Microglia, pesticides, olfactory neurons, progressive supranuclear palsy (PSP), mutation

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2011
Page: [2771 - 2777]
Pages: 7
DOI: 10.2174/138161211797440122
Price: $65

Article Metrics

PDF: 52