Optimizing Scale Up Yield to Pyridazines and Fused Pyridazines

Author(s): Saleh Mohamed Al-Mousawi, Moustafa Sherief Moustafa, Ismail Abdelshafy Abdelhamid, Mohamed Hilmy Elnagdi.

Journal Name: Current Organic Chemistry

Volume 15 , Issue 19 , 2011

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Approaches for the preparation of pyridazines and fused pyridazines are reviewed. Some corrections about errors in the old literature are given and discussed. The %yields of selected examples are optimized.

Keywords: Pyridazines, synthesis, % yield optimization, heterocyclic nucleus, spectroscopic data, lone pair delocalization, cf. resonance, reactions of Mannich bases, Vilsmeier reactions, HMBC data, benzenediazonium chloride, aromatic diazonium salts, malononitrile, phthalazines

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Article Details

Year: 2011
Page: [3503 - 3513]
Pages: 11
DOI: 10.2174/138527211797374760
Price: $58

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