2-Aminoimidazole, Glycociamidine and 2-Thiohydantoin-Marine Alkaloids as Molecular Inspirations for the Development of Lead Structures

Author(s): Ravi Kumar, Shahnawaz Khan, Prem M.S. Chauhan

Journal Name: Current Drug Targets

Volume 12 , Issue 11 , 2011

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Abstract:

This review provides a detailed account on the biological activities of structurally diverse secondary metabolites from marine sponges having 2-aminoimidazole, glycociamidine and/or 2-thiohydantoin ring functions. This review will complement two previous short reviews which did however not address the potential of these natural products for drug discovery. We will discuss the naturally occurring alkaloids and give an account on their structure activity relationships.

Keywords: 2-Aminoimidazole alkaloids, anticancer, antihistaminic, antimicrobial, Glycociamidine, 2-Thiohydantoin, drug discovery, Nagelamides, bioactive agents

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Article Details

VOLUME: 12
ISSUE: 11
Year: 2011
Page: [1689 - 1708]
Pages: 20
DOI: 10.2174/138945011798109428
Price: $65

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