Title: Development of Novel Drug Delivery Prototypes Devices for Targeted Delivery Drug Therapy at the Molecular Level in Aqueous Media
VOLUME: 8 ISSUE: 5
Author(s):Roy George, Theunis Gerhardus Oberholzer and Victoria Tamara Perchyonok
Affiliation:VTPCHEM PTY LTD, Melbourne, 3163, School of Dentistry and Oral Health, Griffith University, Gold Coast 4215, Australia.
Keywords:Molecular prototype, cyclodextrin, drug delivery, free radicals, aqueous, radical affording species, radical quenching species, pH-sensitive, micropartilculate system, chitosan, poly-(glutamic acid), lansoprazole, enteric coated capsule, Freeze dried, acid labile, intestinal delivery, capsule
Abstract: A novel approach in target specific molecular prototype drug delivery system concerns the attempt to employ radical affording substances (RAS) or radical quenching substances (RQS) as prodrugs able to produce irreversible damage on the desired target and therefore to stimulate cellular apoptosis. However, radical species generated can react quickly within the chemical environment prior to reaching its proper site of action. In this short communication, we report our investigations towards developing two alternative novel, simple, flexible and effective drug delivery systems that provide optimal dosage of drugs precisely where and when needed and therefore achieve and sustain a complex delivery profile. We have demonstrated the application of two effective molecular prototype delivery systems able to harness free radical reactivity within the laboratory where biological processes can be studied and controlled, leading to the prevention of disease and the development of new treatments for disease states mediated by free radicals.
