Abstract
It has been well propounded that there exists five basic taste modalities, e.g., sweet, sour, bitter, salty and umami. Recent compelling evidence from rodents and human beings raises the possibility for an additional sixth taste modality devoted to the perception of lipids. A number of studies have suggested that lingual CD36, a glycoprotein, mainly expressed by circumvallate papillae of the tongue, might be implicated in the perception of dietary fat taste. G protein-coupled receptors (GPCRs) are important signaling molecules for many aspects of cellular function. It has been recently shown that these receptors particularly GPR40 and GPR120 might also be involved in lipid taste perception. In this article, we highlight the cell activation mechanisms, responsible for the downstream cell signaling which might help understand the lipid-mediated regulation of feeding behavior, critically involved in the development of several diseases like obesity and other metabolic disorders. We also raise the question whether lipid gustatory cells can be the target of anti-obesity strategies.
Keywords: Lipids, fat, taste receptor cells, fatty acids, linoleic acid, CD36, GPR120, GPR40, obesity, metabolic disorder
Current Medicinal Chemistry
Title: Cell Signaling Mechanisms of Gustatory Perception of Lipids: Can the Taste Cells be the Target of Anti-obesity Agents?
Volume: 18 Issue: 22
Author(s): G. Dramane, S. Akpona, A. M. Simonin, P. Besnard and N. A. Khan
Affiliation:
Keywords: Lipids, fat, taste receptor cells, fatty acids, linoleic acid, CD36, GPR120, GPR40, obesity, metabolic disorder
Abstract: It has been well propounded that there exists five basic taste modalities, e.g., sweet, sour, bitter, salty and umami. Recent compelling evidence from rodents and human beings raises the possibility for an additional sixth taste modality devoted to the perception of lipids. A number of studies have suggested that lingual CD36, a glycoprotein, mainly expressed by circumvallate papillae of the tongue, might be implicated in the perception of dietary fat taste. G protein-coupled receptors (GPCRs) are important signaling molecules for many aspects of cellular function. It has been recently shown that these receptors particularly GPR40 and GPR120 might also be involved in lipid taste perception. In this article, we highlight the cell activation mechanisms, responsible for the downstream cell signaling which might help understand the lipid-mediated regulation of feeding behavior, critically involved in the development of several diseases like obesity and other metabolic disorders. We also raise the question whether lipid gustatory cells can be the target of anti-obesity strategies.
Export Options
About this article
Cite this article as:
Dramane G., Akpona S., M. Simonin A., Besnard P. and A. Khan N., Cell Signaling Mechanisms of Gustatory Perception of Lipids: Can the Taste Cells be the Target of Anti-obesity Agents?, Current Medicinal Chemistry 2011; 18 (22) . https://dx.doi.org/10.2174/092986711796504655
DOI https://dx.doi.org/10.2174/092986711796504655 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
Call for Papers in Thematic Issues
Advances in Medicinal Chemistry: From Cancer to Chronic Diseases.
The broad spectrum of the issue will provide a comprehensive overview of emerging trends, novel therapeutic interventions, and translational insights that impact modern medicine. The primary focus will be diseases of global concern, including cancer, chronic pain, metabolic disorders, and autoimmune conditions, providing a broad overview of the advancements in ...read more
Approaches to the treatment of chronic inflammation
Chronic inflammation is a hallmark of numerous diseases, significantly impacting global health. Although chronic inflammation is a hot topic, not much has been written about approaches to its treatment. This thematic issue aims to showcase the latest advancements in chronic inflammation treatment and foster discussion on future directions in this ...read more
Cellular and Molecular Mechanisms of Non-Infectious Inflammatory Diseases: Focus on Clinical Implications
The Special Issue covers the results of the studies on cellular and molecular mechanisms of non-infectious inflammatory diseases, in particular, autoimmune rheumatic diseases, atherosclerotic cardiovascular disease and other age-related disorders such as type II diabetes, cancer, neurodegenerative disorders, etc. Review and research articles as well as methodology papers that summarize ...read more
Chalcogen-modified nucleic acid analogues
Chalcogen-modified nucleosides, nucleotides and oligonucleotides have been of great interest to scientific research for many years. The replacement of oxygen in the nucleobase, sugar or phosphate backbone by chalcogen atoms (sulfur, selenium, tellurium) gives these biomolecules unique properties resulting from their altered physical and chemical properties. The continuing interest in ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
An Extremely Weak Electric Current System Induces Anti-apoptotic Effects and Anti-necrotic Effects in Living Cells
Current Tissue Engineering (Discontinued) Aldose Reductase Inhibitor, Fidarestat Prevents High-fat Diet-induced Intestinal Polyps in ApcMin/+ Mice
Current Cancer Drug Targets Editorial [Disparity in Pharmacotherapies]
Current Drug Therapy CNS Drug Delivery Systems: Novel Approaches
Recent Patents on Drug Delivery & Formulation Structure-Activity Relationships of Flavonoids
Current Organic Chemistry Methylglyoxal, A Metabolite Increased in Diabetes is Associated with Insulin Resistance, Vascular Dysfunction and Neuropathies
Current Drug Metabolism Effect of Capparis spinosa Extract on Metabolic Parameters in Patients with Type-2 Diabetes: A Randomized Controlled Trial
Endocrine, Metabolic & Immune Disorders - Drug Targets Anti-Tumor Effects of Osthole on Different Malignant Tissues: A Review of Molecular Mechanisms
Anti-Cancer Agents in Medicinal Chemistry Insulin Neuritis and Diabetic Cachectic Neuropathy: A Review
Current Diabetes Reviews Potential Antibacterial Activity of Yemeni Sidr Honey Against <i>Pseudomonas aeruginosa</i> and <i>Streptococcus pyogenes</i>
Anti-Infective Agents Serous BMP8A has Clinical Significance in the Ultrasonic Diagnosis of Thyroid Cancer and Promotes Thyroid Cancer Cell Progression
Endocrine, Metabolic & Immune Disorders - Drug Targets Acknowledgements to Reviewers:
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) COPD and Diabetes Mellitus: Down the Rabbit Hole
Current Respiratory Medicine Reviews Contemporary Roles of the Pediatric Psychologist in Diabetes Care
Current Diabetes Reviews Molecular and Genetic Mechanisms of Obesity: Implications for Future Management
Current Molecular Medicine Meet Our Co-Editor:
Current Medicinal Chemistry Natural Products as Anti-glycation Agents: Possible Therapeutic Potential for Diabetic Complications
Current Diabetes Reviews Effect of Non-Statin Lipid Lowering and Anti-Obesity Drugs on LDL Subfractions in Patients with Mixed Dyslipidaemia
Current Vascular Pharmacology Cell-Permeable Peptide Inhibitor of c-Jun NH2-Terminal Kinase for the Treatment of Diabetes
Current Bioactive Compounds Visfatin/PBEF and Atherosclerosis-Related Diseases
Current Vascular Pharmacology