Title: Nitric Oxide and Cyclic GMP Signaling Pathway as a Focus for Drug Development
VOLUME: 18 ISSUE: 22
Author(s):A.Y. Kots, K. Bian and F. Murad
Affiliation:Department of Biochemistry and Molecular Biology, George Washington University School of Medicine, 2300 Eye Street NW, Ross Hall #530, Washington DC 20052, USA
Keywords:Nitric oxide, cGMP, nitric oxide synthase, guanylyl cyclase, phosphodiesterase, traditional Chinese medicine, drug development, numerous efforts, drug and formulation discovery, promising approaches
Abstract: Recent progress in understanding of the nitric oxide and cGMP signaling pathway provided evidence for mechanism of action of known drugs and identified novel targets for drug development. These discoveries resulted in numerous efforts in drug and formulation discovery. Some of the most promising approaches were applied for efficient therapies of various diseases.
