Vitamin D Therapy in Cardiac Hypertrophy and Heart Failure

Author(s): J. Ruth Wu-Wong

Journal Name: Current Pharmaceutical Design

Volume 17 , Issue 18 , 2011

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Vitamin D3 is made in the skin, modified in the liver to form 25(OH)D, and then further hydroxylated in the kidney to form the active hormone, 1,25-dihydroxyvitamin D3 (calcitriol). Calcitriol binds to and activates the vitamin D receptor (VDR), a nuclear receptor, to regulate numerous downstream signaling pathways in different cells and tissues. Emerging evidence suggests that VDR plays an important role in modulating cardiovascular, immunological, metabolic and other functions. Data from preclinical, epidemiological and clinical studies have shown that deficiency in VDR activation is associated with an increased risk for cardiovascular disease (CVD). Results from interventional trials using either nutritional vitamin D or VDR agonists (VDRAs) support the idea that VDR activation is beneficial for improving the underlying factors of CVD such as hypertension, endothelial dysfunction, atherosclerosis, vascular calcification, cardiac hypertrophy and progressive renal dysfunction. Furthermore, a majority of chronic kidney disease (CKD) patients die of CVD and VDRA therapy is associated with a survival benefit in both pre-dialysis and dialysis CKD patients. Most of the studies measured serum 25(OH)D as an indication for vitamin D deficiency, which does not truly reflect the VDR activation status. Although VDR plays an important role in regulating cardiovascular function and VDRAs may be potentially useful for treating CVD, at present VDRAs are not indicated for the treatment of CVD.

Keywords: Vitamin D, vitamin D receptor, vitamin D receptor agonists, vitamin D deficiency, cardiovascular disease, left ventricular hypertrophy, agonists, deficiency, ventricular, hypertrophy, hemodynamic, hypertension, dysfunction, hospitalization, neonatal, Calcitriol, cardiomyocytes, hyperparathyroidism, keratinocytes, pancreatic -cells

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Article Details

Year: 2011
Page: [1794 - 1807]
Pages: 14
DOI: 10.2174/138161211796391038
Price: $65

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PDF: 15