Recent Advances in the Assembly of Tri-substituted Oxazoles

Author(s): Charles Dylan Turner, Huan Steven Liang

Journal Name: Current Organic Chemistry

Volume 15 , Issue 16 , 2011


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Abstract:

Tri-substituted oxazoles, appearing in several anticancer natural products and various other bioactive compounds, have become increasingly visible in recent years. Research into the synthesis of such oxazoles has led to the development of new synthetic methods as well as refinements of classic methods of their synthesis. In addition, a number of research groups have pursued the synthesis of fully-functionalized-oxazole-containing natural products. We review recent investigations (2004-present) into methods of tri-substituted oxazole synthesis, and the construction of complex natural products containing such oxazoles.

Keywords: Methodology, natural product, tri-substituted oxazole, heterocycles, review, total synthesis, drug discovery, Tri-substituted oxazoles, Nitrogenous heterocycles, myriad, Telomestatin, anticancer activities, Martefragin A, Siphonazole

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Article Details

VOLUME: 15
ISSUE: 16
Year: 2011
Page: [2846 - 2870]
Pages: 25
DOI: 10.2174/138527211796378442
Price: $58

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