Multicomponent Reactions Promoted by Organosilicon Reagents

Author(s): Jie-Ping Wan, Yunyun Liu

Journal Name: Current Organic Chemistry

Volume 15 , Issue 16 , 2011

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Organosillicon reagents have been found as versatile catalysts or promoters for a broad range of organic reactions due to their special properties of multifunction. An important application of organosilicon reagents is in the research field of multicomponent reactions (MCRs), which provides a vast number of practical synthesis for different molecular libraries. We present in this review the recent research progress of MCRs employing organosillicon reagents as catalysts or promoters for the first time.

Keywords: Organosilicon, catalysis, promotion, multicomponent reactions, multicomponent reactions (MCRs), trimethylsilyl chloride (TMSCl), tetrahydro pyrimidinones (THPMs), trimethylsilyl iodide (TMSI), TMSOTf, dimethyl acetylene dicarboxylate (DMAD), cyclic ketones, chemo-selective, diastereoseletivity, Carbon Nucleophiles, hexamethyl disiloxane (HMDS)

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Article Details

Year: 2011
Page: [2758 - 2773]
Pages: 16
DOI: 10.2174/138527211796378479
Price: $58

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