Si-C Coupling Reaction of Hydrosilane with Activated Organic Compounds: A Facile Synthetic Route to Organosilicon Compounds

Author(s): Bok Ryul Yoo, Joon Soo Han

Journal Name: Current Organic Chemistry

Volume 15 , Issue 16 , 2011


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Abstract:

Hydrosilane undergoes useful and interesting Si-C coupling reactions with activated organic compounds such as linear and cyclic alkyl chlorides, polychloromethanes, terminal and internal alkenes, and linear and cyclic conjugated dienes to give a variety of organosilicon compounds with Si-Cl units: 1) thermal induced and Pt-catalyzed hydrosilylation reaction with unsaturated organic compounds, 2) organic salt-catalyzed dehydrochlorinative Si-C coupling reaction with alkyl chlorides, 3) double silylation with olefin, and silylene-trapped ring closure reaction with conjugated dienes. In the quaternary phosphonium chloride-catalyzed dehydrochlorinative Si- C coupling reactions of activated organic compounds with HSiCl3, the reaction with relatively activated allyl chloride and benzyl chloride proceeded at 130 °C to give the corresponding coupling products in good to excellent yields, while that of silylalkyl chlorides and primary/ secondary alkyl chlorides required high reaction temperatures of 150 °C and 170 °C, respectively and long reaction times. Reaction with olefin at the high temperature of 180 °C gave double silylation product in good yield. Conjugated dienes reacted with 1a at 150 °C to afford 1,1-dichlorosilacyclopent-3-ene. This review is designed to organize the Si-C coupling reactions into categories that illustrate distinct patterns of reactivity. It is hoped that an understanding of such patterns will stimulate the use of Si-C coupling reactions in the synthesis of organosilicon compounds.

Keywords: Si-C coupling, hydrosilane, hydrosilylation, carbosilane, Platinum, phosphonium salt, polychloromethanes, organosilicon compounds, olefin, arylsilanes, vinylsilanes, arylfluorosilanes, alkylfluorosilanes, hydrosilanes

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Article Details

VOLUME: 15
ISSUE: 16
Year: 2011
Page: [2743 - 2757]
Pages: 15
DOI: 10.2174/138527211796378424
Price: $58

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