Abstract
Studies on dye-DNA interaction have attracted considerable attention owing to its wide facet of applications in both chemical and biological assays. Cyanine dyes have been extensively used in tracing nucleic acids due to their significant change in colour due to dye-nucleic acid binding. The dyes aggregate on DNA templates and the resultant photophysical characteristics of the aggregates can be exploited to reveal the structure of the template. Interaction of these dyes with peptide nucleic acid has also generated wide interest for unveiling many biochemical processes.
Keywords: Intercalation, minor groove binding, DNA, PNA, nucleic acid, cyanine dye, aggregation, fluorescence probe, chromophoric stereochemical alignment, transoid, DNA-microassay, electrophoresis gels, ethidium bromide, DNA-based photonic wire, fluorescence resonance-energy transfer (FRET)
Current Organic Chemistry
Title: Cyanine Dyes - Nucleic Acids Interactions
Volume: 15 Issue: 15
Author(s): S. Dash, M. Panigrahi, S. Baliyarsingh, P. K. Behera, S. Patel and B. K. Mishra
Affiliation:
Keywords: Intercalation, minor groove binding, DNA, PNA, nucleic acid, cyanine dye, aggregation, fluorescence probe, chromophoric stereochemical alignment, transoid, DNA-microassay, electrophoresis gels, ethidium bromide, DNA-based photonic wire, fluorescence resonance-energy transfer (FRET)
Abstract: Studies on dye-DNA interaction have attracted considerable attention owing to its wide facet of applications in both chemical and biological assays. Cyanine dyes have been extensively used in tracing nucleic acids due to their significant change in colour due to dye-nucleic acid binding. The dyes aggregate on DNA templates and the resultant photophysical characteristics of the aggregates can be exploited to reveal the structure of the template. Interaction of these dyes with peptide nucleic acid has also generated wide interest for unveiling many biochemical processes.
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Cite this article as:
Dash S., Panigrahi M., Baliyarsingh S., K. Behera P., Patel S. and K. Mishra B., Cyanine Dyes - Nucleic Acids Interactions, Current Organic Chemistry 2011; 15 (15) . https://dx.doi.org/10.2174/138527211796367336
DOI https://dx.doi.org/10.2174/138527211796367336 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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