Abstract
The last two decades have been crucial for neurooncology due to the enormous progress in the base research and in the medical technology. Such a continuous development has significantly improved the knowledge on the genetics and molecular biology of brain tumors, thus allowing to better define their prognosis and to find new therapeutic targets. Furthermore, it has provided sophisticated diagnostic and therapeutic tools that have radically changed the behavior of neurosurgeons, neurooncologists, and radiotherapists with regards to these neoplasms. Once considered rare and poorly treatable, infantile brain tumors (IBTs) are currently more and more diagnosed and benefit of the aforementioned progresses so that their prognosis has become quite similar to that of the older ages. The aim of the present paper is to review the factors that favored these advances and to analyze the main aspects concerning IBTs, namely: Current information on epidemiology and etiology; - Advances in the neuroimaging; - Changes in the surgical attitude; - Development of ad hoc chemotherapic and radiotherapic protocols; - The role of pathology and molecular biology in the prognosis; - Outcome; - Future directions.
Keywords: Infantile brain tumor, intracranial neoplasm, neuroimaging, molecular biology
Current Cancer Therapy Reviews
Title: Advances in the Management of Brain Tumors in Infants
Volume: 7 Issue: 3
Author(s): Luca Massimi, Benedetta Pettorini, Gianpiero Tamburrini, Massimo Caldarelli and Concezio Di Rocco
Affiliation:
Keywords: Infantile brain tumor, intracranial neoplasm, neuroimaging, molecular biology
Abstract: The last two decades have been crucial for neurooncology due to the enormous progress in the base research and in the medical technology. Such a continuous development has significantly improved the knowledge on the genetics and molecular biology of brain tumors, thus allowing to better define their prognosis and to find new therapeutic targets. Furthermore, it has provided sophisticated diagnostic and therapeutic tools that have radically changed the behavior of neurosurgeons, neurooncologists, and radiotherapists with regards to these neoplasms. Once considered rare and poorly treatable, infantile brain tumors (IBTs) are currently more and more diagnosed and benefit of the aforementioned progresses so that their prognosis has become quite similar to that of the older ages. The aim of the present paper is to review the factors that favored these advances and to analyze the main aspects concerning IBTs, namely: Current information on epidemiology and etiology; - Advances in the neuroimaging; - Changes in the surgical attitude; - Development of ad hoc chemotherapic and radiotherapic protocols; - The role of pathology and molecular biology in the prognosis; - Outcome; - Future directions.
Export Options
About this article
Cite this article as:
Massimi Luca, Pettorini Benedetta, Tamburrini Gianpiero, Caldarelli Massimo and Di Rocco Concezio, Advances in the Management of Brain Tumors in Infants, Current Cancer Therapy Reviews 2011; 7 (3) . https://dx.doi.org/10.2174/157339411796234933
DOI https://dx.doi.org/10.2174/157339411796234933 |
Print ISSN 1573-3947 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6301 |
Call for Papers in Thematic Issues
Current progress in Protein Degradation and Cancer Therapy
argeted Protein Degradation is gaining momentum in cancer therapy, it facilitate targeting undruggable proteins, it overcome cancer resistance and avoid undesirable side effects. Thus small molecules degraders have emerged as novel therapeutic strategy. Targeted protein degradation (TPD), the process of eliminating a protein of interest hold a great promise for ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
The Use of Herbal Medicine in Cancer-related Anorexia/ Cachexia Treatment Around the World
Current Pharmaceutical Design FOXM1 and its Oncogenic Signaling in Gastric Cancer
Recent Patents on Anti-Cancer Drug Discovery Recent Advancements for the Management of Pancreatic Cancer: Current Insights
Current Cancer Therapy Reviews Natural Products as Modulators of Spermatogenesis: The Search for a Male Contraceptive
Current Molecular Pharmacology Targeting the Ubiquitin-Mediated Proteasome Degradation of p53 for Cancer Therapy
Current Pharmaceutical Design Fertility Preservation in Women After the Cancer
Current Pharmaceutical Design Target-based Anti-angiogenic Therapy in Breast Cancer
Current Pharmaceutical Design Clinical Impact of the Detection of BRAF Mutations in Thyroid Pathology: Potential Usefulness as Diagnostic, Prognostic and Theragnostic Applications
Current Medicinal Chemistry The Life and Death of Protein Kinase C
Current Drug Targets Repair and Translesion DNA Polymerases as Anticancer Drug Targets
Anti-Cancer Agents in Medicinal Chemistry Plant Secondary Metabolites in Cancer Chemotherapy: Where are We?
Current Pharmaceutical Biotechnology Role of Protein Tyrosine Phosphatase in Regulation of Cell Signaling Cascades Affecting Tumor Cell Growth: A Future Perspective as Anti-Cancer Drug Target
Current Pharmaceutical Biotechnology Breast Cancer Image Classification: A Review
Current Medical Imaging Evaluating Potential P-gp Substrates: Main Aspects to Choose the Adequate Permeability Model for Assessing Gastrointestinal Drug Absorption
Mini-Reviews in Medicinal Chemistry Improvement of Nonviral Gene Therapy by Epstein-Barr Virus (EBV)-based Plasmid Vectors
Current Gene Therapy Perineural Invasion in Adenoid Cystic Carcinoma of the Salivary Glands: Anatomical Influences on Oncological Management
Current Cancer Therapy Reviews The Role of microRNA in Ischemic and Hemorrhagic Stroke
Current Drug Delivery Current Advances in the Synthesis and Antitumoral Activity of SIRT1-2 Inhibitors by Modulation of p53 and Pro-Apoptotic Proteins
Current Medicinal Chemistry Differential Role of Apoptosis and Autophagy Associated with Anticancer Effect of Lupulone (Hop β-Acid) Derivatives on Prostate Cancer Cells
Anti-Cancer Agents in Medicinal Chemistry TNFα Modulation of Visceral and Spinal Sensory Processing
Current Pharmaceutical Design