Anticancer Properties of Flavonoids: Roles in Various Stages of Carcinogenesis

Author(s): Nicolas Clere, Sebastien Faure, Maria Carmen Martinez, Ramaroson Andriantsitohaina

Journal Name: Cardiovascular & Hematological Agents in Medicinal Chemistry
Formerly Current Medicinal Chemistry - Cardiovascular & Hematological Agents

Volume 9 , Issue 2 , 2011

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High dietary intake of fruits and vegetables is consistently associated with a reduced risk of common human cancers. The specific mechanisms of action of most phytochemicals in cancer prevention are not yet clear but appear to be varied. One class of compounds currently under investigation is flavonoids, a large group of molecules with similar structure. Although their bioavailability is discussed, numerous in vitro and animal model data suggest that flavonoids modulate important cellular and molecular mechanisms related to carcinogenesis, a multistep process involving the transformation, survival, proliferation, invasion, angiogenesis, and metastasis of the tumor cells. Epidemiological studies confirmed that, among many flavonoids, apigenin, epigallocatechin gallate, delphinidin and genistein appear to be beneficial compounds in various stages of carcinogenesis. Therefore, according to in vitro and in vivo studies, this review attempts to increase our understanding about the preventive and therapeutic effects of these compounds to facilitate extrapolation of results from animal studies to human situations.

Keywords: Flavonoids, apigenin, EGCG, delphinidin, genistein, angiogenesis, carcinogenesis, tumor initiation, tumor progression, metastasis, tumor microenvironment

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Article Details

Year: 2011
Page: [62 - 77]
Pages: 16
DOI: 10.2174/187152511796196498
Price: $65

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