Target-directed Discovery and Bioprocess Engineering of New Enzymes for Environmentally Benign Production of High-Value Chiral Chemicals

Author(s): Ling Ou, Hui-Lei Yu, Jian-He Xu

Journal Name: Current Organic Chemistry

Volume 15 , Issue 14 , 2011

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Herein we give a brief account of the efforts our group made in recent years to discover novel enzymes and utilize them by bioprocess engineering techniques for stereoselective synthesis of various enantiomerically pure chiral chemicals with high value in a greener manner. Included are discussions on oxidoreductases, expoxide hydrolases and glucosidases in whole cells or isolated form from microorganisms or plants.

Keywords: Target-directed discovery, Biocatalysis, Oxidoreductases, Expoxide hydrolases, Glucosidases, Bioprocess engineering, Reductases, Rhodotorula sp. AS2.2241, Bacillus sp. ECU0013, Adzuki Bean Ketone Reductases, Pseudomonas putida ECU1009, Glycolate Oxidase, Alcaligenes sp. ECU0401, Rhodococcus sp. ECU0066, EPOXIDE HYDROLASES

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Article Details

Year: 2011
Page: [2519 - 2529]
Pages: 11
DOI: 10.2174/138527211796150598
Price: $58

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PDF: 11